Residential surrounding greenness and DNA methylation: An epigenome-wide association study

R Xu; S Li; S Li; EM Wong; MC Southey; JL Hopper; MJ Abramson; Y Guo

Journal article

Residential surrounding greenness and DNA methylation: An epigenome-wide association study

R Xu, S Li, S Li, EM Wong, MC Southey, JL Hopper, MJ Abramson, Y Guo

Environment International | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2021

DOI: 10.1016/j.envint.2021.106556

Abstract

Background: DNA methylation is a potential biological mechanism through which residential greenness affects health, but little is known about its association with greenness and whether the association could be modified by genetic background. We aimed to evaluate the association between surrounding greenness and genome-wide DNA methylation and potential gene-greenness interaction effects on DNA methylation. Methods: We measured blood-derived DNA methylation using the HumanMethylation450 BeadChip array (Illumina) for 479 Australian women, including 66 monozygotic, 66 dizygotic twin pairs, and 215 sisters of these twins. Surrounding greenness was represented by Normalized Difference Vegetation ..

View full abstract

University of Melbourne Researchers

Shuai Li Author

Melissa Southey Author

Related Projects (1)

A twin study of breast cancer and epigenetics

We will conduct a study of more than 500 Australian female twin pairs in which one or both have had breast cancer. We will also study measur..

Grants

Awarded by Boehringer Ingelheim

Funding Acknowledgements

Funding RX was supported by China Scholarship Council (grant number 201806010405) . SSL was supported by an Early Career Fellowship of the Australian National Health and Medical Research Council (NHMRC, grant number APP1109193) . YG was supported by a Career Development Fellowship of the Australian National Health and Medical Research Council (grant number APP1163693) . SL was supported by an Early Career Research Fellowship of the Victorian Cancer Agency (ECRF 19020) . MCS is a NHMRC Senior Research Fellow (grant number APP1155163) . JLH is a NHMRC Senior Principal Research Fellow. The Australian Mammographic Density Twins and Sisters Study (AMDTSS) was facilitated through access to Twins Research Australia, a national resource supported by a Centre of Research Excellence Grant (grant number 1079102) from the NHMRC. The AMDTSS was supported by NHMRC (grant numbers 1050561 and 1079102) , Cancer Australia and National Breast Cancer Foundation (grant number 509307) .